Identification of erythroferrone as an erythroid regulator of iron metabolism

Dr. Rivella was part of a team that discovered a new hormone ERFE that mediates hepcidin suppression during stress erythropoisesis. ERFE expression is greatly increased in mice with thalassemia intermedia, where it contributes to hepcidin suppresion and iron overload characteristics of the disease. Published in Nature Genetics on June 2014.